"Screaming" Jay Hawkins was born and raised in Cleveland, Ohio. At the age of 18 months, Hawkins was put up for adoption and shortly thereafter was adopted and raised by Blackfoot Indians. Hawkins studied classical piano as a child and learned guitar in his 20s. In a 1993 interview, Hawkins recounts telling his music tutor, ...to leave before I make your life miserable [...] because with the type of music I want to play. The things I want to do with music and don't want to do it the old conventional way that everybody knows. I want to come up with my own ideas. I've got all the information that I need to get from you to do what I want, now if you stick around, I'm going to make your life miserable.
His initial goal was to become an opera singer (Hawkins cited Paul Robeson as his musical idol in interviews), but when his initial ambitions failed, he began his career as a conventional blues singer and pianist. Other influences included Mario Lanza, Enrico Caruso, Lionel Hampton, Dizzy Gillespie, Charles Brown, Amos Milburn, Wynonie Harris, Nellie Lutcher, Roy Brown, Jimmy Witherspoon, Eddie "Cleanhead" Vinson, Roy Milton, Elmore James, Lightnin' Hopkins and H-Bomb Ferguson.
He joined the US Army with a forged birth certificate in 1942 (aged 13), and allegedly served in a combat role, with his fellow soldiers and higher-ups around him ignoring the fact he was substantially underage. During this time, he also entertained the troops as part of his service. In 1944, he enlisted in the Army Air Forces, being honorably discharged in 1952. Hawkins was an avid and formidable boxer during his years in the US Army (and later Air Force) boxing circuit. In 1949, he was the middleweight boxing champion of Alaska. In 1951, he joined guitarist Tiny Grimes' band, and was subsequently featured on some of Grimes' recordings. When Hawkins became a solo performer, he often performed in a stylish wardrobe of leopard skins, red leather, and wild hats.
Hawkins' later releases included "Constipation Blues" (which included a spoken introduction by Hawkins in which he states he wrote the song because no one had written a blues song before about "real pain"), "Orange Colored Sky", and "Feast of the Mau Mau". Nothing he released, however, had the monumental success of "I Put a Spell on You". In Paris in 1999 and at the Taste of Chicago festival, he actually performed "Constipation Blues" with a toilet onstage.
He continued to tour and record through the 1960s and 1970s, particularly in Europe, where he was very popular. Hawkins released a single recording of mainstream ballads in 1969, "Too Many Teardrops" and the Hawaiian styled "Makaha Waves" on the flip-side. In February 1976, he suffered facial injuries when he was burned by one of his flaming props while performing with his guitarist Mike Armando at the Virginia Theater in Alexandria, Virginia. He appeared in performance (as himself) in the Alan Freed bio-pic American Hot Wax in 1978. Subsequently, filmmaker Jim Jarmusch featured "I Put a Spell on You" on the soundtrack – and deep in the plot – of his film Stranger Than Paradise (1983) and then Hawkins himself as a hotel night clerk in his Mystery Train and in roles in Álex de la Iglesia's Perdita Durango and Bill Duke's adaptation of Chester Himes' A Rage in Harlem.
In 1983, Hawkins relocated to the New York area. In 1984 and 1985, Hawkins collaborated with garage rockers the Fuzztones, resulting in Screamin' Jay Hawkins and the Fuzztones Live album recorded at Irving Plaza in December 1984. They performed in the 1986 movie Joey.
In 1990, Hawkins performed the song "Sirens Burnin'," which was featured in the 1990 horror film Night Angel.
In July 1991, Hawkins released his album Black Music for White People. The record features covers of two Tom Waits compositions: "Heart Attack and Vine" (which, later that year, was used in a European Levi's advertisement without Waits' permission, resulting in a lawsuit), and "Ice Cream Man" (a Waits original and not a cover of the John Brim classic). Hawkins also covered the Waits song "Whistlin' Past the Graveyard", for his album Somethin' Funny Goin' On. In 1993, his version of "Heart Attack and Vine" became his only UK hit, reaching No. 42 on the UK singles chart. In 1993, Hawkins moved to France.
When Dread Zeppelin recorded their "disco" album, It's Not Unusual in 1992, producer Jah Paul Jo asked Hawkins to guest. He performed the songs "Jungle Boogie" and "Disco Inferno". He also toured with the Clash and Nick Cave during this period, and not only became a fixture of blues festivals but appeared at many film festivals as well, including the Telluride Film Festival premiere of Mystery Train.
His 1957 single "Frenzy" (found on the early 1980s compilation of the same name) was included in the compilation CD, Songs in the Key of X: Music from and Inspired by the X-Files, in 1996. This song was featured in the show's Season 2 episode "Humbug". It was also covered by the band Batmobile.
In 2001, the Greek director and writer Nicholas Triandafyllidis made the documentary Screamin' Jay Hawkins: I Put a Spell on Me about various stages of his life and career, including a filming of his last-ever live performance, in Athens on December 11, 1999, two months before his death, following a performance the day before in Salonica. In the documentary notable artists such as Jim Jarmusch, Bo Diddley, Eric Burdon, Frank Ash, Arthur Brown and Michael Ochs talked about Screamin' Jay Hawkins' early life, personality and career, and about his incredible talent.
Hawkins died after emergency surgery from an aneurysm on February 12, 2000, in Neuilly-sur-Seine, France, near Paris, at 70 years old.